The error message "Sorry, this application cannot run under a Virtual Machine" is a persistent issue for players of Dead Space 3, particularly on modern Windows 10 and 11 systems. This error is triggered by the game's built-in Digital Rights Management (DRM), which identifies certain standard Windows security features as a virtual environment. Common Causes of the False Positive

Windows 10/11 Security Features: Features like Memory Integrity (HVCI) use virtualization to protect the system kernel, which can trigger the error.

Go to Control Panel > Programs and Features > Turn Windows features on or off.

Warning: This weakens some security features. Revert the values to 1 after finishing Dead Space 3.

Windows 10 and 11 use background virtualization for security, which often triggers this false positive.