Open Systems Pharmacology

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Reliable, powerful and easy-to-use modeling & simulation tools for pharmaceutical and other life-sciences applications. Qualified and accepted by the scientific community including academia, regulatory agencies and industry. Available free to everyone.

Essentials

Download OSP Suite

Explore the full functionality of the OSP suite. PBPK, PBPK/PD, QSP – the OSP Suite gives you the flexibility to build it all without having to start from scratch.

Forum

Have your questions answered or provide answers to others. The Forum is a great way to stay up-to-date on the community buzz around OSP.

Documentation

Need to find out how to use a feature? Looking to understand the inner workings of the model? Here you’ll find the extensive OSP manual and qualification documents.

News & Release

Save the Date: OSP Community Conference 2026

In Beerse, Antwerp September 24th and 25th

Open Systems Pharmacology Suite - Version 12 Update 2

We are pleased to announce the new release of the OSP Suite Version 12 Update 2 which is now available for download.

WORKSHOP AT ACOP COLORADO.

Join ESQlabs at the ACoP Conference in Colorado Building Scalable PBPK-QSP Models - Modularization in MoBi for OSP Suite V12.

Ready to take the plunge? Download

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The transgender community and the broader LGBTQ+ culture are bound by a shared history of resistance, a common fight for civil rights, and a vibrant tapestry of shared spaces. While "LGBTQ+" serves as an umbrella term, the "T" represents a distinct journey of gender identity that has both anchored and revolutionized the movement.

The Transgender Community and LGBTQ Culture: Understanding the Intersection shemale 3gp hit best

Disproportionate Homelessness

According to the National Center for Transgender Equality, trans individuals are four times more likely to live in extreme poverty than cisgender people. Trans youth are twice as likely to experience homelessness. When a child comes out as trans, the rejection rate by religious or conservative families remains devastatingly high. In response, the queer community has built an infrastructure of mutual aid. From binding (chest flattening) donation drives to GoFundMe campaigns for gender confirmation surgeries, the "LGBTQ culture" of caring for one's own is most acutely embodied in how cis queers show up for their trans siblings. The transgender community and the broader LGBTQ+ culture

1. The Bathroom vs. The Bedroom

The gay rights movement has historically fought for the right to love in private. The trans movement fights for the right to exist in public. The fight for marriage equality was about legal recognition of a relationship; the fight for bathroom access is about the basic human necessity of relieving oneself without fear of assault. This shift from privacy to visibility has been uncomfortable for some in the mainstream gay community who achieved success through the strategy of “we’re just like you.” Trans existence, particularly non-binary existence, challenges the very notion of “just like you.” Increase Funding : Increase funding for organizations and

  1. Increase Funding: Increase funding for organizations and programs that support trans individuals and LGBTQ individuals, particularly in areas such as mental health, employment, and education.
  2. Promote Visibility: Promote visibility and representation of trans individuals and LGBTQ individuals in media, politics, and other areas of public life.
  3. Pass Policy Reforms: Pass policy reforms, such as the Equality Act and the GIEN Act, to protect the rights of trans individuals and LGBTQ individuals.
  4. Build Community: Build community and support for trans individuals and LGBTQ individuals, particularly in areas such as mental health, employment, and education.

The Intersection of Language and Identity

LGBTQ culture has always been a crucible of language. Terms like "shade," "tea," "slay," and "kiki" originated in Black and Latinx queer and trans spaces before becoming internet slang. The act of choosing one’s own name and pronouns—a sacred act for trans individuals—has also influenced how the broader LGBTQ community thinks about identity fluidity.

If you or someone you know is struggling with gender identity or facing discrimination, contact The Trevor Project (1-866-488-7386) or the Trans Lifeline (877-565-8860).

The Shift from "Transgendered" to "Transgender"

The grammatical shift away from "transgendered" (implying something was done to a person) to "transgender" (an adjective describing a state of being) reflects a deeper cultural shift toward dignity. Similarly, terms like "assigned male at birth" (AMAB) and "assigned female at birth" (AFAB) have moved from medical charts into everyday queer discourse, allowing people to discuss biology without reducing identity to it.

Publications & Models

Models

Glucose Insulin Model

Scientifically exciting for diabetes researchers. Technically exciting for everyone with PBPK models of glucose, insulin, and glucagon coupled through non-mechanistic PD as well as systems pharmacology PD models.

Publications

Journal Publications

Growing list of scientific journal publications that relates to OSP or describes work with PK-Sim® or MoBi®. Add your own contributions and label them or others appropriately to further grow and structure this database.

Take a look at all our models Browse

Management Team

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